Selective Serotonin reuptake Inhibitors or SSRIs

Selective serotonin reuptake
inhibitors or SSRIs

Paroxetine is a commonly used
antidepressant, from the class of drugs known as selective serotonin reuptake inhibitors or SSRIs.


Following content taken from Wikipedia( Drug information


Several studies have suggested that
paroxetine can be used in the treatmentof premature ejaculation. In particular,intravaginal ejaculation latency time (IELT) was found to increase with 6– 13-fold, which was somewhat longer than the delay achieved by the treatment with other SSRIs (fluvoxamine, fluoxetine, sertraline, and


However,paroxetine taken acutely (“on demand”) 3–10 hours before coitus resulted only
in a “clinically irrelevant and sexually unsatisfactory” 1.5-fold delay of ejaculation and was inferior to clomipramine, which induced a fourfold delay.
The reason it causes a delay
in ejaculation is because it greatly
reduces sex drive, in some cases,
causing an inability to gain an erection or ejaculate. SSRIs are also effective in the treatment of severe premenstrual syndrome ;
however, paroxetine is contraindicated in women who may
become pregnant due to its
teratogenicity and its high risk of
withdrawal syndrome in both adults and neonates.



Author: renjiveda

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