Atorvastatin

Atorvastatin
Pharmacokinetic data
Bioavailability 12%
Metabolism Hepatic – CYP3A4
Half-life 14 h
Excretion Bile

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Member of the drug class known as statins, used for lowering blood cholesterol.
It also stabilizes plaque and prevents strokes through
anti-inflammatory and other
mechanisms.
Like all statins, atorvastatin works by inhibiting HMG- CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.

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The primary uses of atorvastatin is for the treatment of dyslipidemia and the prevention of cardiovascular disease .

It is recommended to be used only after other measures such as diet, exercise, and weight reduction have not improved cholesterol levels.

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Contraindications
Active liver disease: cholestasis ,
hepatic encephalopathy, hepatitis , and jaundice Unexplained elevations in AST or ALT
levels Pregnancy
Breastfeeding

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Precaution must be taken when treating with atorvastatin, because rarely it may lead to rhabdomyolysis

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Author: renjiveda

I'm not I

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